"Novel Methods and Emerging Targets in Drug Discovery & Patented Drug Development"
Announcement
The congress will be held on 19-21 December, 2019 at the BAU-Besiktas Campus, Istanbul
Congress Starting Date:
December 19, 2019
Congress Location
Istanbul - TURKEY
Organiser
Bahcesehir University



















Scientific Program
19 DECEMBER 2019 – B CONFERENCE HALL, BESIKTAS, ISTANBUL


08:00-09:30 Registration
09:30-10:00 Opening Ceremony
10:00-10:30 Challenges in Identifying Epitope Regions of Intrinsically Disordered Proteins by Classical Molecular Dynamics Simulations & Impact of Glycosylation on Intrinsically Disordered Proteins by Quantum Mechanics and Artificial Intelligence ORKIDE COŞKUNER WEBER


10:30-11:00 COFFEE BREAK


SESSION-I
Panel Chairs : ORKIDE COŞKUNER WEBER, MİNE YURTSEVER


11:00-11:30 Dual function of HSP70 in cytoprotection of tumor cells and generation of permissive microenvironment HASAN KORKAYA
11:30-11:55 Rewiring the epigenetic networks as a therapeutic approach in MLLrarranged leukemias CEYDA AÇILAN AYHAN
11:55-12:15 Novel research tools to modulate molecular basis of diseases and potential drug candidates FATİH KOCABAŞ
12:15-12:35 Interactome Analysis of Protein-Protein Interaction Networks Reveals Critical Signaling Hubs in Cancer Cells GİZEM DİNLER DOĞANAY


12:35 – 13:30 LUNCH


SESSION-II
Panel Chairs : GİZEM DİNLER DOĞANAY, CEYDA AÇILAN AYHAN


13:30-14:00 Controlling Conformational Transitions in Proteins by Combined Methodological Approaches CANAN ATILGAN
14:00-14:25 High-resolution evolutionary analysis of membrane proteins in the health context OGUN ADEBALI
14:25-14:50 Cancer Nano-Theranostics: The Novel Application of Nanotechnology in Simultaneous Diagnosis and Treatment of Cancer ALİ ZARRABİ
14:50-15:05 What we can learn by evaluating partition coefficient prediction methods about the accuracy of protein-ligand affinity predictions? MEHTAP IŞIK
15:05-15:15 Coarse-grained simulations as a tool to study drug encapsulation properties and molecular structure of tri-block copolymers GÖKHAN KAÇAR
15:15-15:25 In silico and in vitro studies of Allatostatin Receptor type C of Thametopoea pityocampa (T.pit); as a next-generation pesticide target AIDA SHAHRAKI
15:25-15:45 Applications of Dissolving Microneedles: A New Oppurtunity for Efficient and Safe Treatment MUHAMMET AVCIL


15:45-16:00 COFFEE BREAK


SESSION-III
Panel Chairs : CANAN ATILGAN, OGUN ADEBALI


16:00-16:25 Design of Monoamine Oxidase Enzyme (MAO) Inhibitors by Multidimensional Computational Methods MİNE YURTSEVER
16:25-16:50 Insight into the Mechanochemical Cycle of Cytoplasmic Dynein from Molecular Dynamics Simulations MERT GÜR
16:50-17:10 Rationally Designing antisense therapy to keep up with evolving bacterial resistance ENES KOTİL
17:10-17:25 In the quest of the most plausible dimerization interface of the AT1R İSMAİL EROL
17:25-17:40 Virtual Screening of Curcumin Derivatives for MAO-A Inhibition MAHMOUD MIRZAEI
18:00-19:00 POSTER PRESENTATIONS-I


20 DECEMBER 2019, FRIDAY - B CONFERENCE HALL, BESIKTAS, ISTANBUL


SESSION-IV
Panel Chairs : MERT GÜR, BÜLENT ÖZPOLAT


09:15-09:45 Identifying New Drug Targets to Stop Energy Wasting Linked to Cancer Cachexia SERKAN KIR
09:45-10:15 Network-based metabolism-centered screening of potential drug targets in Klebsiella pneumoniae at genome scale TUNAHAN ÇAKIR
10:15-10:30 Structural Characterization of Huntingtin N-terminus Fragment BEYTULLAH ÖZGÜR
10:30-10:45 First MD Simulations of Full Structure HIV1/GP120 in Complex with CD4 and CCR5 BERNA DOĞAN


10:45-11:15 COFFEE BREAK


SESSION-V
Panel Chairs : İSMAİL YALÇIN, ELİF ÖZKIRIMLI ÖLMEZ


11:15-11:45 Development of Targeted Therapies for Breast and Aggressive Cancers BÜLENT ÖZPOLAT
11:45-12:10 Target misfolded protein clearance pathway for cancer therapy APAR PATAER
12:10-12:20 In Situ Protein Diversification by CRISPR/Cas9-induced DNA Repair MUTLU ERDOGAN
12:20-12:30 AYŞEGÜL GÖKÇE (Clarivate Analytics)


12:30-13:30 LUNCH


SESSION VI
Panel Chairs : MUSTAFA GÜZEL, MOHAMMAD RAMZI


13:30-14:00 Structure-Activity Relationship Analysis of Some New 2,5-Disubstituted Benzoxazoles as hGSTP1-1 Enzyme Inhibitors İSMAİL YALÇIN
14:00-14:30 NLRP7’s Essential Role in Human Embryogenesis: Patient Derived Trophoblasts as a Model for Hydatidiform Molar Pregnancy Disease NESRİN ÖZÖREN
14:30-14:55 Exploring chemical space for drug discovery using natural language processing methodologies ELİF ÖZKIRIMLI ÖLMEZ
14:55-15:05 Doxorubicin Loading Capacity and Drug Delivery Efficiency of Purified Short Length Multi Walled Carbon Nanotubes BİRCAN DİNÇ
15:05-15:15 Evaluation of Anti-Proliferative Activities of Some Protic Ionic Liquids HÜSEYİN AKBAŞ
15:15-15:30 TÜBİTAK BİLİM İNSANI DESTEKLEME PROGRAMLARI BAŞKANLIĞI (BİDEB) BURS VE DESTEK PROGRAMLARI HAKKINDA BİLGİLENDİRME YASİN TOKDEMİR


15:30-16:00 COFFEE BREAK


SESSION VII
Panel Chairs : THOMAS MAVROMOUSTAKOS, ESİN AKI YALÇIN


16:00-16:30 Nuclear Export Inhibitors for Cancer Therapy MOHAMMAD RAMZI
16:30-16:55 New Medicines and Hopes to Fight Cancer: Anti-Cancer Effects of Novel Caffeic Acid Phenethyl Ester (CAPE) Analogues on Glioblastoma Multiforme (GBM) Cell Lines MUSTAFA GÜZEL
16:55-17:10 Synthesis, biological investigation and molecular docking studies of β-lactam derivatives bearing thiadiazole and oxadiazole moiety ARİF MERMER
17:10-17:25 Design, Synthesis and Anti-proliferation Activity of Novel Maleimide-based Glycogen Synthase Kinase-3 (GSK-3) Inhibitors ÖMER TAHİR GÜNKARA
17:25-17:40 Co-Delivery of Water-Insoluble Active Biomolecules by Emulsomes MEHMET HİKMET ÜÇIŞIK
17:45-18:15 SHORT TALKS-I
Tripalmitin-based Emulsome Formulations for Sustained Delivery of Antileishmanial Compounds to Infected Macrophages ZEYNEP İŞLEK
Investigation of antitumor activity of organoruthenium (II)-arene complexes coordinated with thiosemicarbazones synthesized in colorectal cancer cell lines DUYGU ERDOĞAN
Physicochemical and Biological Characterization of a Biosimilar IgG1 CEMRE YAŞAR
Potent Novel Inhibitors Against Hepatitis C Virus NS3 (HCV NS3 GT-3a) Protease Domain SAIMA IKRAM
Elucidation of Fludarabine-DNA Interactions Using Molecular Docking Studies SOYKAN AĞAR
Two-Photon Absorption Properties of Gold Fluorescent Protein YUSUF ŞİMŞEK
Imine Bond Bearing Water Soluble Tridentate Ligand and Cu (II), Ni (II), and Zn (II) Complexes: Synthesis, Characterization and Anticancer Activities BURCU SAYGIDEĞER DEMİR
A Novel Hydrogenation of Nitroarene Compounds in The Presence of BINAP.PdCl2 in Aqueous Medium NURSEFA ZENGIN
18:15-19:15 POSTER PRESENTATIONS-II


21 DECEMBER 2019, SATURDAY - B CONFERENCE HALL, BESIKTAS, ISTANBUL


SESSION VIII
Panel Chairs : SALİH GENCER, YASIN ŞENBABAOĞLU


09:15-09:45 Medicinal Chemist and Rational Drug Design THOMAS MAVROMOUSTAKOS
09:45-10:15 Repurposing of PARP Inhibitors for Inherited Retinal Degeneration AYŞE ŞAHABOĞLU
10:15-10:40 Structural Bioinformatics Approaches for Early Drug Discovery against Infectious Diseases ÖZLEM TAŞTAN BISHOP
10:40-10:50 Using phytochemicals as β-lactamase inhibitors to cope antibiotic resistance: In-silico and in-vitro study MEHBOOB AHMED


10:50-11:15 COFFEE BREAK


SESSION IX
Panel Chairs : JAMSHAID AHMAD, TİMUÇİN AVŞAR


11:15-11:45 Mechanism of action of benzimidazoles as cholinesterase inhibitors ESİN AKI YALÇIN
11:45-12:15 Bioactive Sphingolipids in Cancer Biology and Therapy: TGF-β receptor I/II Trafficking and Signaling at Primary Cilia are Inhibited by Ceramide to Attenuate Cell Migration and Tumor Metastasis SALİH GENCER
12:15-12:40 Integrating Ligand and Target-Driven Based Virtual Screening Approaches with in vitro human Cell Line Models to Identify Novel Hit Compounds Against BCL-2 SERDAR DURDAĞI


12:40-13:30 LUNCH


SESSION X
Panel Chairs : AYŞE ŞAHABOĞLU, ÖZLEM TAŞTAN BISHOP


13:30-14:00 Machine learning identifies neurally programmed tumors across 33 cancer types YASIN ŞENBABAOĞLU
14:00-14:25 Screening of FDA approved drugs for finding potential inhibitor for Granzyme B as a potent drug-repurposing target JAMSHAID AHMAD
14:25-14:40 Array based detection of proteins in human serum using conjugates of gold nano-particles and green fluorescent protein HANDAN AKPINAR
14:40-14:50 Novel AChE and BChE Inhibitors Using Combined Virtual Screening, Text mining and in vitro Binding Assays KADER ŞAHİN
14:50-15:00 Determination of pharmacophore group showing drug effect in isatin derivatives and bioactivity calculation KADER ŞAHİN
15:00-15:10 Is thiol disulfide balance important in diagnosis of acute cholecystitis? KAYHAN ÖZDEMİR
15:10-15:35 Ethical Issues Concerning the Relationships Between Medical Practitioners and the Pharmaceutical Industry KADIRCAN KESKINBORA


15:35-16:00 COFFEE BREAK


SESSION XI
Panel Chairs : ENES KOTİL, BERNA DOĞAN


16:00-16:25 Proteomics Analysis in Multiple Sclerosis: Investigation of Disease Associated Molecular Pathways and Markers TİMUÇİN AVŞAR
16:25-16:40 Synthesis and anticancer activity of non-symmetrical urea derivative BÜNYAMİN ÖZGERİŞ
16:40-16:50 Development of Nanoparticle-based Point-of-Care Diagnostics Platform for Determining Alkaline Phosphatase Activity from Saliva OYA AKÇA
16:50-17:00 Computational approach for generating robust models for discovering novel imidazo[2,1-b]thiazole derivatives as pantothenate synthetase inhibitors EFE DOĞUKAN DİNCEL
17:00-17:10 Computational Designing and Preclinical Studies of Acetylcholinesterase Inhibitors: A Common Treatment to Various Neurodegenerative Disorders HAFSA AMAT UR RASOOL
17:10-17:20 Green synthesis of biocompatible hyaluronic acid conjugate using hydroquinone and lavender extract for a broad range of cosmetic and biomedical applications VESEN ATIROĞLU
17:20-17:30 Crosslink collagen from cow stomach with low molecular weight hyaluronic acid for cosmetic application ATHEER ATIROĞLU
17:30-18:15 SHORT TALKS-II
Combination Treatment With YK-4-279 Enhances Cisplatin Chemosensitivity in A549 Non-Small Cell Lung Cancer Cell Line Through Alteration of EGFRSTAT3 Signaling Pathway Via Regulation of APE1 SARA ALKHATIB
In Vitro Therapeutic Effects of Novel Methyl Jasmonate Derivatives on Brain Cancer Cell Lines DAMLA ULUDAĞ
Action Mechanism of Novel Nimesulide Derivatives as Potential Antiinflammatory Compounds with Secondary Anticancer Effects ADEM ÖZLEYEN
Design, synthesis and biological evaluation of some novel benzimidazole derivatives as Topoisomerase I inhibitors ASAF EVRIM EVREN
Molecular modelling and antiviral activity of 1H-indole-2,3-dione derivatives carrying naphthalene moiety ÖZGE SOYLU
Synthesis and computer-aided drug design studies of novel 4-aryl-1,2,4triazole-3-thione derivatives as potent and target-oriented therapeutic agents EFE DOĞUKAN DİNCEL
Design and synthesis of novel furoyl piperazine bearing benzothiazole derivatives as cholinesterase inhibitors ASAF EVRIM EVREN
A Tool for Investigating Protein Signaling Network by Perturbation of External Energy Dissipation MUSTAFA ERHAN ÖZER
Exploring dynamics of pMHC using accelerated molecular dynamics ELIF NAZ BINGÖL
18:30-19:00 CLOSING CEREMONY AND POSTER AWARDS
 
 
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